| L | May 11May 11, 2022 | MHP RIESEN Ludwigsburg vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 7 | 4 | 0 | 1 | 0 | 33.3% | 50.0% |
| L | May 1May 1, 2022 | ALBA BERLIN vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 6 | 5 | 0 | 2 | 0 | 20.0% | 50.0% |
| L | Apr 29Apr 29, 2022 | MLP Academics Heidelberg vs BMA365 Bamberg BasketsBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 14 | 6 | 2 | 1 | 0 | 36.4% | 100.0% |
| L | Apr 23Apr 23, 2022 | MLP Academics Heidelberg vs EWE Baskets OldenburgBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 12 | 6 | 0 | 1 | 0 | 57.1% | 50.0% |
| L | Apr 18Apr 18, 2022 | MLP Academics Heidelberg vs Telekom Baskets BonnBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 5 | 7 | 1 | 1 | 0 | 33.3% | 50.0% |
| L | Apr 12Apr 12, 2022 | ratiopharm ulm vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 24 | 11 | 1 | 1 | 0 | 61.5% | 83.3% |
| L | Apr 9Apr 9, 2022 | HAKRO Merlins Crailsheim vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 13 | 4 | 1 | 1 | 1 | 45.5% | 0.0% |
| W | Mar 29Mar 29, 2022 | MLP Academics Heidelberg vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 11 | 5 | 1 | 0 | 0 | 33.3% | 50.0% |
| L | Mar 26Mar 26, 2022 | MLP Academics Heidelberg vs Veolia Towers HamburgBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 15 | 3 | 3 | 1 | 2 | 57.1% | 100.0% |
| W | Mar 23Mar 23, 2022 | BG Göttingen vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 18 | 10 | 0 | 1 | 2 | 71.4% | 70.0% |
| L | Mar 19Mar 19, 2022 | Fitness First Würzburg Baskets vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 6 | 9 | 0 | 0 | 1 | 40.0% | 100.0% |
| W | Mar 12Mar 12, 2022 | MLP Academics Heidelberg vs Basketball Löwen BraunschweigBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 13 | 9 | 1 | 2 | 1 | 38.5% | 0.0% |
| W | Feb 16Feb 16, 2022 | MLP Academics Heidelberg vs SYNTAINICS MBCBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 16 | 5 | 3 | 1 | 0 | 70.0% | 66.7% |
| L | Feb 12Feb 12, 2022 | BBC Bayreuth vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 14 | 4 | 2 | 1 | 0 | 45.5% | 66.7% |
| L | Feb 5Feb 5, 2022 | MLP Academics Heidelberg vs NINERS ChemnitzBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 18 | 9 | 1 | 2 | 0 | 46.2% | 100.0% |
| L | Feb 2Feb 2, 2022 | EWE Baskets Oldenburg vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 18 | 3 | 0 | 1 | 0 | 58.3% | 50.0% |
| L | Jan 23Jan 23, 2022 | MLP Academics Heidelberg vs FC Bayern München BasketballBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 8 | 4 | 1 | 1 | 1 | 44.4% | 0.0% |
| W | Jan 15Jan 15, 2022 | Basketball Löwen Braunschweig vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 23 | 12 | 1 | 0 | 0 | 46.2% | 80.0% |
| W | Jan 7Jan 7, 2022 | MLP Academics Heidelberg vs HAKRO Merlins CrailsheimBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 22 | 6 | 0 | 0 | 2 | 57.1% | 100.0% |
| L | Dec 30Dec 30, 2021 | SKYLINERS vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 19 | 9 | 1 | 1 | 1 | 55.6% | 100.0% |
| L | Dec 27Dec 27, 2021 | MLP Academics Heidelberg vs ratiopharm ulmBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 17 | 9 | 1 | 1 | 0 | 33.3% | 100.0% |
| L | Dec 19Dec 19, 2021 | MLP Academics Heidelberg vs ALBA BERLINBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 18 | 5 | 1 | 2 | 0 | 63.6% | 75.0% |
| L | Dec 10Dec 10, 2021 | Telekom Baskets Bonn vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 5 | 4 | 1 | 0 | 0 | 12.5% | 75.0% |
| L | Dec 6Dec 6, 2021 | FC Bayern München Basketball vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 11 | 4 | 1 | 3 | 1 | 44.4% | 0.0% |
| L | Dec 4Dec 4, 2021 | MLP Academics Heidelberg vs BG GöttingenBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 26 | 7 | 1 | 1 | 0 | 56.3% | 60.0% |
| L | Nov 21Nov 21, 2021 | NINERS Chemnitz vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 15 | 9 | 1 | 1 | 1 | 33.3% | 83.3% |
| L | Nov 6Nov 6, 2021 | MLP Academics Heidelberg vs BBC BayreuthBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 17 | 8 | 1 | 1 | 1 | 42.9% | 62.5% |
| L | Oct 29Oct 29, 2021 | Veolia Towers Hamburg vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 7 | 7 | 1 | 0 | 1 | 50.0% | 100.0% |
| W | Oct 23Oct 23, 2021 | MLP Academics Heidelberg vs Fitness First Würzburg BasketsBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 18 | 7 | 2 | 1 | 4 | 35.7% | 75.0% |
| L | Oct 17Oct 17, 2021 | BMA365 Bamberg Baskets vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 3 | 4 | 2 | 0 | 1 | 20.0% | 25.0% |
| W | Oct 9Oct 9, 2021 | GIESSEN 46ers vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 6 | 8 | 1 | 1 | 1 | 22.2% | 66.7% |
| W | Sep 29Sep 29, 2021 | MLP Academics Heidelberg vs MHP RIESEN LudwigsburgBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 8 | 12 | 2 | 3 | 1 | 37.5% | 50.0% |
| W | Sep 25Sep 25, 2021 | SYNTAINICS MBC vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 17 | 6 | 2 | 1 | 1 | 70.0% | 50.0% |
